Bogomoletz Institute of Physiology. National Academy of Sciences, Ukraine

 Department of General and Molecular Pathophysiology

Oksana Klymenko, MD, PhD


Mob. +38-093-815-50-99;
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

RESEARCH AND TEACHING POSITION

Since Oct 2018 Researcher of Bogomoletz Institute of Physiology (Department of General and
Molecular Pathophysiology), NAS of Ukraine.
Aug 2016 – Sept 2018 Junior Researcher of Bogomoletz Institute of Physiology, NAS of Ukraine.

EDUCATION

Feb 2018 Doctor of Philosophy (PhD), pathological physiology, Kiev, Ukraine.
Oct 2012 – Sep 2015 PhD student of Bogomolets Institute of Physiology NASU,  pathological physiology, Kiev, Ukraine.
Sep 2002 – Jul 2009 Medical Doctor (General Medicine) National Medical University, Kiev, Ukraine,

 

OBJECTIVE: Researcher in the fields of molecular pathophysiology, molecular biology, genetics, cell biology, molecular physiology.

Research Interests

1. Genetic and epigenetic approaches of response on different type of hypoxia (oxidative stress, anoxia/reoxygenation, ischemia/reperfusion).
2. HIF-? subunits role in normal and pathological conditions.
3. Investigations of hypoxic lncRNA and miRNA expression and its pathways of regulation at oxidative stress, ischemia/reperfusion modelling.


PUBLICATIONS

https://www.researchgate.net/profile/Oksana_Klymenko
https://scholar.google.com.ua/citations?user=lNx-od0AAAAJ&hl=uk&authuser=1

LAB SKILLS AND INSTRUMENTS:

•Reverse transcription PCR,
•RNA-interference
- RNA, DNA isolation techniques
•Cardiohemodynamics using Millar ultra-catheters
•Culture of neonatal cardiomyocytes
•Fluorescence microscopic techniques (determination of apoptosis, necrosis, autophagy,
quantifications of intracellular organelles and protein, measurement of mitochondrial
potential)
•Animal handling experience
- Neonatal contractility activity measurement

LANGUAGES

Russian, Ukrainian - native
English – fluent


Journal Publications

T. Drevytska, E. Gonchar, I. Okhai, O. Linnyk, I. Mankovska, D. Klionsky, V. Dosenko: The protective effect of Hif3a RNA interference and HIF-prolyl hydroxylase inhibition on cardiomyocytes under anoxia-reoxygenation. Life Sciences 04/2018; 202., DOI:10.1016/j.lfs.2018.04.021

Oksana Linnik, Tetyana I. Drevytska, K. Tarasova, Georgiy Portnichenko, Viktor E. Dosenko, Irina N. Mankovskaya: Doxorubicin-Induced Disturbances of Cardiomyocyte Contractile Activity. 01/2018; 9(1):9-16., DOI:10.1615/IntJPhysPathophys.v9.i1.20

O. Linnik, O. Gonchar, V. Nosar, T. Drevytska, O. Kovalyov, I. Mankovska: EFFECT OF CURCUMIN ON MITOCHONDRIAL FUNCTION OF CARDIOMYOCYTES WITH DOXORUBICININDUCED OXIDATIVE STRESS. Fiziolohichny? zhurnal 02/2017; 63(1):10-16., DOI:10.15407/fz63.01.010

O. Linnik, T. Drevytska, K. Tarasova, G. Portnichenko, V. Dosenko, I. Mankovska: DOXORUBICIN-INDUSED DISTURBANCES OF CARDIOMYOCYTE CONTRACTILE ACTIVITY. Fiziolohichny? zhurnal 12/2016; 62(6):65- 71., DOI:10.15407/fz62.06.065

Linnik OO, Drevytska TI, Gonchar OO, Chornyy SA, Kovalyov OM, Mankovska IM: DOXORUBICIN-INDUCED ALTERATIONS IN PRO-AND ANTIOXIDANT BALANCE AND THEIR CORRECTION BY CURCUMIN IN THE NEONATAL RAT CARDIOMYOCYTES CULTURE.  Fiziologicheski? zhurnal 10/2015; 61(5):90-98., DOI:10.15407/fz61.05.090

Conference Proceedings

Tetjana Drevytska, K Tarasova, O Linnyk, V Dosenko: The effect of pharmacological KATP channels activation on contractile function and gene expression of isolated neonatal rat cardiomyocytes under doxorubicin induced oxidative stress. HEART FAILURE, EUROPEAN JOURNAL OF HEART FAILURE; 05/2017


O.Linnik, T.Drevytska: IS IT NECESSARY HIF-3? ACTIVATION? IN VITRO AND IN VIVO STUDY.. ІІІ Conferense of young scientists " Physiology: from molecules to the body", Kiev, Ukraine; 10/2013, DOI:10.13140/2.1.1242.0486


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